Rheumatoid factor RF is the autoantibody that was first found in rheumatoid arthritis. Rheumatoid factor can also be a cryoglobulin antibody that precipitates on cooling of a blood sample ; it can be either type 2 monoclonal IgM to polyclonal IgG or type 3 polyclonal IgM to polyclonal IgG cryoglobulin. Although predominantly encountered as IgM, rheumatoid factor can be of any isotype of immunoglobulins , i. RF is often evaluated in patients suspected of having any form of arthritis even though positive results can be due to other causes, and negative results do not rule out disease. But, in combination with signs and symptoms , it can play a role in both diagnosis and disease prognosis.
Rheumatoid Factors RF are autoantibodies that react with individuals own immunoglobulin. These antibodies are usually directed against the Fc fragment of the human IgG. Of these IgM and IgG are the most common. The formation of immune complex in the joint space leads to the activation of complement and destructive inflammation, causing rheumatoid arthritis RA. A number of methods are available for testing of RF.
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